Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
2022.01.14 17:51
장소 | KI bldg. 5th fl. Room B501 & Zoom |
---|---|
일시 | Jan. 18(Tue), 2pm-3pm |
연사 | YoungJu Jo (Stanford University) |
[Seminar]
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
Zoom: https://kaist.zoom.us/j/89586032430
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
YoungJu Jo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].
References:
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
댓글 0
번호 | 일시 | 장소 | 연사 | 제목 |
---|---|---|---|---|
232 | June 14 (THU), 10:00 AM | E6-2, 2nd fl. #2502 | Prof. Kenji Toyoda |
Phonons and polariton-like particles in trapped ions for quantum computation and quantum simulation
![]() |
231 | Jun. 2 (Fri.), 4:00 PM | #1323 (E6-2. 1st fl.) | Dr. Sang Wook Kim |
Maxwell's demon in quantum wonderland
![]() |
230 | Jun. 2 (Fri.), 02:30 PM | E6-2. 1st fl. #1323 | Dr. Euyheon Hwang(황의헌) |
Quasiparticle Interference and Fourier transform scanning tunneling spectroscopy in WTe2 (Weyl semimetal)
![]() |
229 | Jun. 18 (MON), 10:00 AM | E6-2. 2nd fl. #2502 | Dr. Thibault VOGT |
Rydberg electromagnetically induced transparency and microwave-to-optical conversion using Rydberg atoms
![]() |
228 | Jun. 16 (Thu) 4PM | #1323(E6-2, 1st fl.) | Hyochul Kim, Samsung Advanced Institute of Technology | Quantum information processing using quantum dots and photonic crystal cavities |
227 | Jun. 14 (Tue) 4PM | Seminar Room (#2502, 2nd fl.) | Young-Sik Ra, Université Pierre et Marie Curie | Photonic quantum network based on multimode squeezed vacuums and single-photon subtraction |
226 | Jun. 11 (Fri.), 04:00 PM | Online seminar | Dr. Keun Su Kim(Yonsei University) |
Pseudogap in surface-doped black phosphorus
![]() |
225 | Jun. 11 (Fri.), 02:30 PM | Online seminar | Dr. Jin Woong Cha(KRISS) |
Engineering sound waves and vibrations in multi-mode nanomechanical systems
![]() |
224 | Jun. 10 (Fri.), 11:00 AM | Online seminar | Dr. Yoon Jang Chung(Laboratory for Physical Sciences, University of Maryland) |
Record-quality two-dimensional electron systems
![]() |
223 | Jun. 10 (Fri.), 04:00 PM | E6-2. 1st fl. #1323 | Dr. Sanghoon Kim(Department of Physics, University of Ulsan) |
Fe5GeTe2의 나선형 자성특성과 자기저항의 전류밀도 의존성 연구
![]() |
222 | Jun. 10 (Fri.), 02:30 PM | E6-2. 1st fl. #1323 | Dr. Seunghun Lee(Department of Physics, Pukyong National University) |
Combinatorial strategy for condensed matter physics: study on rare earth hexaborides thin films
![]() |
221 | Jun. 1(Wed) 10:30 AM | BK21 Conference Room (#1318, E6-2) | Dr. Noriaki Horiuchi, Editor, Nature Photonics | Welcome to Nature Photonics |
220 | Jun. 01 (Fri.), 11:00 AM | E6-2. 1st fl. #1323 | Dr. Seung Sae Hong |
Topological phases in low-dimensional quantum materials
![]() |
219 | Jun 8 (Tue), 10:00 AM | Zoom webinar | Toshihiko Baba (Yokohama National University, Japan) |
Photonic crystal devices for sensing
![]() |
218 | Jun 28, 14:00 | E6-2, #1322 | Dr. Bongjae Kim, Dr. Sooran Kim, Dr. Jeongwoon Hwang |
1st Research-exchange meeting of computational material physics
![]() |
217 | Jun 24 (Mon) 11:00 | E6-2, #1323 | Dr. Henning Schomerus |
Topological photonic anomalies
![]() |
216 | Jun 22(Tue) 17:00 | Zoom webinar | Wei Han (Peking University, China) |
Spintronics meets Quantum Materials
![]() |
215 | Jun 1 (Wed) 4 PM | #1323(E6-2 1st fl.) | Kil-Byoung Chai, Caltech | Laboratory experiments relevant to mesospheric clouds, Saturn’s rings & astrophysical jets |
214 | July. 14 (Fri.), 3:00 PM | #1323 (E6-2. 1st fl.) | Dr. Jun Hyun Lee / University of Maryland |
Chiral anomaly in disordered Weyl semimetals
![]() |
213 | July 9 (Mon.), 14:00 PM | #1323, E6-2 | Prof. Cesar A. Hidalgo, MediaLab, MIT |
The principles of collective learning
![]() |