visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
484 2011-09-03 16:00  E6, 1501  Physics Colloquium : 2011 Fall file
483 2022-10-13 16:00  E6-2 #1323  (광학분야 세미나) Ultrafast Optics for Ultra-Precision Metrology and Realization of Flexible/Stretchable Laser-Induced-Graphene Electronics
482 2020-11-12 16:00  E6-2 1323  2020 가을학기 광학분야 특별세미나
481 2022-10-07 11:00  E6-2 #1323  [Update 세미나 영상] (응집물리 세미나) Competing orders in a vanadium-based kagome metal monolayer file
480 2022-10-28 11:00  E6-2 #1323  [Update 세미나영상] (응집물리 세미나) Machine-Learning-Guided Prediction models and Materials discovery for high Tc cuprates file
479 2017-10-10 16:00  E6-2 #1323  Discovery of New 2D Materials with Diverse Physical Properties
478 2023-04-06 16:00  E6-2 #1323  (광학분야 세미나)Nanophotonics-based approaches to explore Berry physics
477 2022-11-17 16:00  E6-2 #1323  (광학분야 세미나) Ultrastructural and Spectroscopic Studies by Super-Resolution Fluorescence Microscopy
476 2022-09-22 16:00  E6-2 #1323  (광학분야 세미나) Quasi-particle-like optical vortices in magnetic materials
475 2022-02-28 16:00  E6, #1501  Spin-based training of optical microscopes
474 2022-12-09 11:00  E6-2 #1323  [Update 세미나영상](응집물리 세미나) Single-shot measurements of strongly-correlated artificial molecular levels in semiconductor quantum dots file
473 2023-03-24 11:00  E6-2 #1323  (응집물리 세미나)Floquet simulators of topological surface states in isolation
472 2023-05-18 16:00  E6-2 #1323  (광학분야 세미나)Dielectric metasurfaces for optimized optical system and spatial light modulators
471 2022-05-10 16:00  E6 1323  (광학분야 특별세미나)Testing quantum thermodynamics using quantum optics
470 2022-05-30 16:00  E6, #1501  Light manipulation using 2D layered semiconductors
469 2022-09-29 16:00  E6-2 #1323  (광학분야 세미나) Ultrafast THz Field-Induced Nonlinear Optics
468 2013-03-11 16:00  E6, 1501  Physics Colloquium : 2013 Spring
467 2023-05-31 16:00  E6-2, #2502  [High-Energy Theory Seminar] Resurgence and complex Chern-Simons theory
» 2022-01-18 14:00  KI bldg. 5th fl. Room B501 & Zoom  Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo file
465 2016-06-14 16:00  Seminar Room (#2502, 2nd fl.)  Photonic quantum network based on multimode squeezed vacuums and single-photon subtraction