visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
일시 May 22th(Mon), 1:00pm 
장소 E6-6 119 
연사 Dr. John Bosco Balaguru Rayappan (SASTRA Deemed University) 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
 
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)


Abstract:
The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
 
번호 날짜 장소 제목
499 2018-05-31 16:00  #1323, E6-2  Dynamic control of optical properties with gated-graphene metamaterials file
498 2018-06-22 16:00  #1323, E6-2  Tuning functional properties of BiFeO3 films using strain and growth chemistry file
497 2018-06-22 16:00  #1323, E6-2  Tuning functional properties of BiFeO3 films using strain and growth chemistry file
496 2018-07-09 14:00  #1323, E6-2  The principles of collective learning file
495 2018-10-25 16:00  #1323, E6-2  Abelian and non-Abelian dark photons file
494 2018-10-26 16:00  #1323, E6-2  Coexisting triple-point and nodal-line topological magnons and thermal Hall effect in pyrochlore iridates file
493 2018-11-01 16:00  #1323, E6-2  Direct holography from a single snapshot file
492 2018-11-08 16:00  #1323, E6-2  Conformality lost file
491 2018-11-21 15:00  #1323, E6-2  Engineering topological quantum physics at the atomic scale file
490 2018-11-29 16:00  #1323, E6-2  양자 칸델라 실현을 위한 단일 광자 발생장치 개발 file
489 2019-04-04 16:00  #1323, E6-2  Chiral spin-photon interaction at nanoscale file
488 2019-04-11 16:00  #1323, E6-2  Massive screening for cathode active materials using deep neural network file
487 2019-04-19 11:00  #1323, E6-2  First-principles studies of semiconductors for solar cell applications file
486 2019-04-23 16:00  #1323, E6-2  From Mott physics to high-temperature superconductivity file
485 2019-04-26 16:00  #1323, E6-2  Robust Quantum Metrology using Strongly Interacting Spin Ensembles and Quantum Convolutional Neural Network file
484 2019-05-01 16:00  #1323, E6-2  Raman and x-ray scattering study on correlated electron systems: two case examples file
483 2019-05-02 16:00  #1323, E6-2  Anomalous optical properties of halide perovskites file
482 2019-05-08 16:00  E6 Room(#1323)  Imaging valley dependent electron transport in 2D semiconductors file
481 2019-05-09 16:00  #1323, E6-2  Quantum Optical Sensing Using Single Photons And Single Photon Emission from Single Emitters file
480 2019-05-09 16:00  #1323, E6-2  Quantum Optical Sensing Using Single Photons And Single Photon Emission from Single Emitters file