Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
|장소||KI bldg. 5th fl. Room B501 & Zoom|
|일시||Jan. 18(Tue), 2pm-3pm|
|연사||YoungJu Jo (Stanford University)|
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior . Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics .
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
|220||2015/11/06, 4:30 PM||E6-2, #5318||Dr. Youngkuk Kim (University of Pennsylvania)||Topological Dirac line nodes in centrosymmetric semimetals|
|219||2015/10/23, 3PM||E6-2, #5318||Dr. Helmut Soltner (Forschungszentrum Juelich)||Development of a Rogowski Coil as a new beam position monitor|
|218||2015/08/03,10:30AM||E6-2, #1323 (Seminar Room)||Dr. Jonghee Yoo (Fermi National Accelerator Laboratory, USA )||Axion Search|
|217||July 31(Wed.)/ 16:00||E6-2, #1323||Dr. Ivan Borzenets||Features of ballistic superconducting graphene|
|216||July 25(Thur.),4:00PM||E6-2, #1323||Prof.Bohm-Jung Yang||Band topology of twisted bilayer graphene|
|215||Jun 24 (Mon) 11:00||E6-2, #1323||Dr. Henning Schomerus||Topological photonic anomalies|
|214||2016/09/29-12/13||E6-2, #1323||Sangyoon Han 외||2016 Fall, Physics Seminar Serises|
|213||2016/1/26, 2PM||E6-2, #1323||Dr. Sergei V. Kalinin (Center for Nanophase Materials Sciences, Oak Ridge National Laboratory)||Electrochemistry on Nano- and Atomic Levels: Scanning Probe Microscopy Meets Deep Data|
|212||2016/1/11, 4PM||E6-2, #1323||Dr. B.J.Kim (Max Planck Institute for Solid State Research)||Mott Physics in the Strong Spin-Orbit Coupling Regime|
|211||2015/12/11, 3:45PM||E6-2, #1323||Dr. Ji Hun Sim (POSTECH)||Dynamical mean field theory studies on heavy fermion system|
|210||2015/12/11, 1:30PM||E6-2, #1323||Dr. KwangYong Choi (Chung-Ang University)||Quantum spin liquid in the 1/3 depleted triangular lattice Ba3(Ru1-xIrx)Ti2O9|
|209||2015/12/09, 2PM||E6-2, #1323||Arjun G. Yodh (University of Pennsylvania)||SWELLABLE COLLOIDAL PARTICLES ARE SWELL|
|208||2015/12/03, 4PM||E6-2, #1323||Dr. Sang-Yun Lee (3rd institute of Physics, University of Stuttgart, Germany)||Hybrid solid state spin qubits in wide bandgap semiconductors|
|207||2015/12/02, 4PM||E6-2, #1323||Dr. Dae-Jeong Kim (Dept. of Physics and Astronomy, University of California, Irvine)||Samarium Hexaboride: Is it a Topological insulator?|
|206||2015/12/01, 4PM||E6-2, #1323||Dr. Yeong Kwan Kim(Lawrence Berkeley National Laboratory, USA)||Introducing extra dimensions to spectroscopic studies of advanced quantum materials|
|205||2015/11/28, 10AM||E6-2, #1323||Dr. Suyong Jung (Korea Research Institute of Standards and Science)||Electron Tunneling Spectroscopy of Single and Bilayer Graphene with Hexagonal Boron Nitride as Tunneling Barrier|
|204||2015/11/23, 1:30PM||E6-2, #1323||Dr. Michael Park (Stanford University)||What's Beyond the Standard Model? Lessons from Run I and what might come in Run II|
|203||2015/11/19, 4PM||E6-2, #1323||Dr. Daesu Lee (University of Wisconsin-Madison)||Emergent Collective Phenomena and Functions at Reduced Dimensions|
|202||2015/11/24, 4PM||E6-2, #1323||Dr. Kab-Jin Kim (Institute for Chemical Research, Kyoto University, Japan)||Topology-based understanding of spin dynamics in inhomogeneously magnetized systems|
|201||2015/11/10, 4PM||E6-2, #1323||Dr. Woosuk Bang (Physics division, Los Alamos National Laboratory)||Rapid heating of matter using high power lasers|