Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
2022.01.14 17:51
장소 | KI bldg. 5th fl. Room B501 & Zoom |
---|---|
일시 | Jan. 18(Tue), 2pm-3pm |
연사 | YoungJu Jo (Stanford University) |
[Seminar]
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
Zoom: https://kaist.zoom.us/j/89586032430
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
YoungJu Jo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].
References:
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
댓글 0
번호 | 일시 | 장소 | 연사 | 제목 |
---|---|---|---|---|
212 | Mar. 25(Fri.) 11:00 | E6-1 #1323 | Prof. Ara Go (Department of Physics, Chonnam National University) |
(응집물리 세미나) Hund's metallicity in ruthenate systems
![]() |
211 | May 20(Fri.) 11:00 | E6-1 #1323 | Prof. Kwanpyo Kim (Department of Physics, Yonsei University) | (응집물리 세미나) Exploration of new polymorphs in van der Waals crystals |
210 | October 24 (Wed.), 10:30 AM | E6-1, Lecture Room 1501(1F) | Prof. Kerry J. Vahala |
Photonic integration of next-generation clocks and Hertz-absolute-accuarcy optical frequenncy synthesizers
![]() |
209 | DEC. 26 (Wed), 04:00 PM | E6-1. 3rd fl. #3434 | Y. Kim, A. Go, K. Hwang and E.-G. Moon |
Informal Workshop on Topology and Correlation
![]() |
208 | June 3(Fri.) 11:00 | E6-2 #1323 | Prof. Gil Young Cho (Department of Physics, POSTECH) | (응집물리 세미나) Theoretical Investigation of Exotic Quantum States in Low-dimensional Materials |
207 | Oct 23 (Fri.), 14:00 PM | E6-2 #1323 | Prof. Ivan Savenko (University of Science and Technology & IBS PCS) |
Plasmon spectroscopy of low-dimensional superconductors in fluctuating regime
![]() |
206 | Oct. 10(Tue) 4PM | E6-2 #1323 | 김성웅 교수 (성균관대학교 에너지과학과) | Discovery of New 2D Materials with Diverse Physical Properties |
205 | Sep. 29th(Thu), 4PM | E6-2 #1323 (1st floor) | Dr. Sangyoon Han, Department of Physics, KAIST | Large-scale Silicon Photonic MEMS Switches |
204 | Nov. 12 (Thu.) 4:00 PM | E6-2 1323 | 김영덕 (Young Duck Kim) 교수 | 2020 가을학기 광학분야 특별세미나 |
203 | Jan. 17(Mon) - 21 (Fri), 2-4pm | E6-2 Room 2502 | Dr. Donghui Jeong (Penn State University) |
Five Lectures on Observational Probes of Dark Energy
![]() |
202 | Sep. 02(Fri) 4:00 PM | E6-2(1st fl) #1323 | Dr. Yong-Joo Doh, Department of Physics and Photon Science, GIST | Quantum Electrical Transport in Topological Insulator Nanowires |
201 | Sep. 02(Fri) 2:30 PM | E6-2(1st fl.), #1323 | Dr. Yong-Hyun Kim,Graduate School of Nanoscience and Technology, KAIST | Nanoscale Thermal Physics: Seebeck Effect and Nanoscale Friction |
200 | Jun 28, 14:00 | E6-2, #1322 | Dr. Bongjae Kim, Dr. Sooran Kim, Dr. Jeongwoon Hwang |
1st Research-exchange meeting of computational material physics
![]() |
199 | 2015/11/28, 10AM | E6-2, #1323 | Dr. Suyong Jung (Korea Research Institute of Standards and Science) | Electron Tunneling Spectroscopy of Single and Bilayer Graphene with Hexagonal Boron Nitride as Tunneling Barrier |
198 | 2015/11/19, 4PM | E6-2, #1323 | Dr. Daesu Lee (University of Wisconsin-Madison) | Emergent Collective Phenomena and Functions at Reduced Dimensions |
197 | 2015/11/24, 4PM | E6-2, #1323 | Dr. Kab-Jin Kim (Institute for Chemical Research, Kyoto University, Japan) | Topology-based understanding of spin dynamics in inhomogeneously magnetized systems |
196 | 2015/11/23, 1:30PM | E6-2, #1323 | Dr. Michael Park (Stanford University) | What's Beyond the Standard Model? Lessons from Run I and what might come in Run II |
195 | 2015/12/03, 4PM | E6-2, #1323 | Dr. Sang-Yun Lee (3rd institute of Physics, University of Stuttgart, Germany) | Hybrid solid state spin qubits in wide bandgap semiconductors |
194 | 2015/12/11, 1:30PM | E6-2, #1323 | Dr. KwangYong Choi (Chung-Ang University) | Quantum spin liquid in the 1/3 depleted triangular lattice Ba3(Ru1-xIrx)Ti2O9 |
193 | 2015/11/10, 4PM | E6-2, #1323 | Dr. Woosuk Bang (Physics division, Los Alamos National Laboratory) | Rapid heating of matter using high power lasers |