• HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
일시 May 22th(Mon), 1:00pm 
장소 E6-6 119 
연사 Dr. John Bosco Balaguru Rayappan (SASTRA Deemed University) 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)

The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
번호 날짜 장소 제목
527 2018-09-07 15:00  학술문화관 (E9), 2층 양승택 오디토리움  Recent developments in density functional theory: From new functionals to the nature of the chemical bond file
526 2016-05-17 11:00  창의학습관(E11), 406호  The CERN Resonant WISP Search: Development, Results and Lesson-Learned
525 2022-05-13 16:00  자연과학동(E6-2) 1st fl. #1323  High-fidelity iToffoli gate for fixed-frequency superconducting qubits file
524 2021-11-02 16:00  자연과학동(E6-2) #1323  Metrology of Band Topology via Resonant Inelastic X-ray Scattering file
523 2017-12-13 13:30  자연과학동 대형강의실 (1501호)  KAIST-KIAS Joint Workshop in Theoretical Sciences 개최 file
522 2021-05-27 16:00  온라인  찾아가는 물리연구 현장(유럽 입자물리학연구소 소개) file
521 2018-08-01 11:00  양분순 빌딩 (E16-1) 207호  Future of AI: Is the brain a computer? file
520 2022-04-01 16:00  Zoom webinar  High-field Electron Transport and Interaction Induced Phenomena in 2D Materials file
519 2020-09-14 17:30  Zoom webinar  KAIST Global Forum for Spin and Beyond (Third Forum) file
518 2022-05-13 14:30  Zoom webinar  Topological Superconducting Spintronics Towards Zero-Power Computing Technologies file
517 2020-09-22 09:30  Zoom webinar  Physics and applications of soliton microcombs(Quantum- & Nano-Photonics) file
516 2020-08-17 20:00  Zoom webinar  Using magnetic tunnel junctions to compute like the brain file
515 2021-06-08 10:00  Zoom webinar  Photonic crystal devices for sensing file
514 2021-04-19 19:00  Zoom webinar  Evidence of Electrical Switching in Antiferromagnets and Coherent Spin Pumping file
513 2020-08-25 20:00  Zoom webinar  KAIST Global Forum for Spin and Beyond (Second Forum) file
512 2020-09-28 17:30  Zoom webinar  KAIST Global Forum for Spin and Beyond(Fourth Forum) file
511 2021-12-03 16:00  Zoom webinar  Nonequilibrium Heat Transport in Elemental Metals Probed by an Ultrathin Magnetic Thermometer file
510 2021-05-17 17:00  Zoom webinar  Spin current generation and detection in uniaxial antiferromagnets file
509 2021-12-03 14:30  Zoom webinar  Topological Spin Textures: Skyrmions and Beyond file
508 2021-04-09 10:00  Zoom webinar  Integrated Lithium Niobate Photonics file