Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
|장소||KI bldg. 5th fl. Room B501 & Zoom|
|일시||Jan. 18(Tue), 2pm-3pm|
|연사||YoungJu Jo (Stanford University)|
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior . Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics .
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
|222||Dec. 9(Fri), 1:30 p.m.||#1323(E6-2. 1st fl.)||Dr. Jae Yoon Cho, POSTECH||Entanglement area law in strongly-correlated systems|
|221||Dec. 9(Fri), 4p.m.||#1323(E6-2. 1st fl.||Dr. Kun Woo Kim, KIAS||Shift Charge and Spin Photocurrents in Dirac Surface States of Topological Insulator|
|220||Dec.10(Thu), 01:55 PM||Zoom||Yin Wen (University of Tokyo)||Consistency of Boltzmann equation and light dark matter from inflaton decay|
|219||Dec.23(Wed), 10:00~16:00||Online||Prof. YongKeun Park (KAIST) and etc.||Online workshop for Quantitative Phase Imaging|
|218||Dec.9(Wed), 10:00AM||Zoom||Prof. Andrew Geraci (Northwestern University)||Searching for the QCD axion with the ARIADNE experiment|
|217||December 13 (Fri.), 1:00 PM||#2501, E6-2||Dr. Chang-Jong Kang||Computational Material Designs: Current Status and Future Directions|
|216||December 13 (Fri.), 1:30-4:30 PM||#1323, E6-2||Biophysics Mini-symposium at KAIST|
|215||December 18 (Tue.), 4:00 PM||#1323, E6-2||Prof. Shin-ichi Uchida||Road to Higher Tc Superconductivity|
|214||December 2(Wed), 10:00AM||Zoom||Prof. Rakshya Katiwada (Illinois Institute of Technology)||Recent progress in Axion Dark Matter eXperiment (ADMX) technology|
|213||December 27(Fri.), 15:00||E6-2,#5318||Han Gyeol Suh||The superconducting order parameter puzzle of Sr2RuO4|
|212||December 3 (Tue.), 4:00 PM||#1323, E6-2||Dr. Jong Mok Ok||Toward Quantum Materials with Correlated Oxides|
|211||December 5 (Thu.), 16:00 PM||#1323, E6-2||Prof. Soon-Hong Kwon||Subwavelenth Photonic Devices: From Single Photon Sources to Solar Cell|
|210||Feb. 1 (Wed.), 2p.m.||#1323(E6-2. 1st fl.)||Dr. Michihisa Yamamoto, Department of Applied Physics, The University of Tokyo||Quantum electron optics using flying electrons|
|209||Feb. 12 (Mon), 3:00pm||#C303, (Creation Hall 3F, KAIST Munji Campus)||Dr. Byeongsu Yang, Kamioka Observatory, Univ. of Tokyo||The recent result of XMASS Experiment|
|208||Feb. 2(Tue) 2:30 PM||Zoom||Prof. Sangsik Kim (Texas Tech University, USA)||Quantum- & Nano-Photonics 세미나(Integrated Nanophotonics with Metamaterials, Microcomb, and Atomic Systems)|
|207||Feb. 25 - Jun 3||Rm. 1501 (E6)||Spring 2019: Physics Colloquium|
|206||Feb.15(Mon), 05:00PM||Zoom||Yoshichika Otani(Tokyo Univ.)||Magnetic Cluster Octupole Domain evolutation in chiral antiferromagnets|
|205||Feb.17(Wed)~19(Fri), 09:00~11:00AM||Online||Prof. Subir Sachdev (Harvard University)||석학 대중 강연 및 강의 시리즈|
|204||February 12(Web.)||E6-2, #5318||Prof. Kunio Kaneta||From inflation to new weak-scale|
|203||February 13th (Thur.), 16:30 PM||E6-6, #119||Dr. Seyoon Kim(University of Wisconsin-Madison)||Enhanced Light-Matter Interactions in Graphene with Noble Metal Plasmonic Structures|