visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
479 2022-05-19 15:00  online  (광학분야 특별세미나)Development of a multimodal optical system for improved disease diagnosis
478 2022-03-31 16:00  online  (광학분야 특별세미나)Ultrafast time-resolved spectroscopy in topological materials
477 2022-05-19 15:00  online  (광학분야 특별세미나)Development of a multimodal optical system for improved disease diagnosis
476 2020-11-20 14:30  Online  Lumpy Cooper pairs in an iron-based superconductor
475 2021-03-02 16:00  Online  Sensitive terahertz detection with graphene-based transistors file
474 2020-12-11 16:00  online  Atomic and electronic reconstruction at van der Waals interface in twisted 2D materials
473 2020-12-23 10:00  Online  Online workshop for Quantitative Phase Imaging file
472 2020-11-20 16:00  Online  Coherent control of field gradient induced quantum dot spin qubits
471 2020-12-11 14:30  online  Antisymmetric interlayer exchange coupling in magnetic multilayers
470 2021-02-17 09:00  Online  석학 대중 강연 및 강의 시리즈 file
469 2016-09-05 16:00  Natual Scien Bldg.(E6)m #1501  Physics Colloquium : 2016 Fall file
468 2016-05-19 15:00  May 19, 2016 (Thur.) 3PM,  The CERN Resonant WISP Search: Development, Results and Lesson-Learned
467 2017-01-09 16:00  Lecture Hall, College of Natural Sciences [#1501,E6-2]  Topological Defects and Phase Transitions" file
466 2016-04-18 15:30  KI빌딩(E4), 강의실 B501 (5F)  First Principles Approaches for Intermolecular Interactions: From Gas-Phase Dimers to Liquid Water and Molecular Crystal Polymorphism file
465 2014-05-28 17:00  KI Building, Matrix Hall  부품소재산업이 미래다
464 2022-08-09 14:00  KI building (E4), Lecture Room Red (B501)  Quantum biology in fluorescent protein: a new model system to study quantum effects in biology file
463 2023-02-20 17:00  KI building (E4), Lecture Room Red (B501)  (Optics Seminar) Neural Holography for Next generation Virtual and Augmented Reality Displays file
» 2022-01-18 14:00  KI bldg. 5th fl. Room B501 & Zoom  Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo file
461 2016-08-04 14:30  KAIST Natural Science Building (E6-5), EDU 3.0 Room(1st fl.)  Relational Logic (with applications to Quantum Mechanics, String Theory, Cosmology, Neutrino Oscillations, Statistical Mechanics)
460 2016-04-04 09:30  KAIST Natural Science Building (E6-2), RM #4314  Radio frequency engineering