visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
연사  
장소 KI bldg. 5th fl. Room B501 & Zoom 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 연사 제목
공지 2025-02-24 16:00    2025년 봄학기 콜로키움 안내
공지 2025-02-27 16:00    2025년 봄 물리학과 특별세미나 (광학/응집물리 분야)
546 2023-04-28 11:00    Tkachenko wave: From the modern field theory viewpoint
545 2018-10-18 10:00    Understanding membrane protein folding using single-molecule force techniques file
544 2023-07-19 16:00    [High-Energy Theory Seminar]Deriving the Simplest Gauge-String Duality
543 2023-03-02 11:00    Probing Anomalies of Non-Invertible Symmetries with Symmetry TFTs
542 2020-07-02 16:00    An irreversible qubit-photon coupling for the detection of itinerant microwave photons file
541 2015-08-04 11:00    Propagation of ultrasound through two- and three-dimensional strongly scattering media
540 2016-07-07 14:00    Let there be topological superconductors
539 2017-09-22 13:00    Superconductor-metal-insulator transition in thin Tantalum films file
538 2017-06-02 14:30    Quasiparticle Interference and Fourier transform scanning tunneling spectroscopy in WTe2 (Weyl semimetal) file
537 2016-05-24 16:00    Electronic and magnetic properties of 2D transition-metal thiophosphates and tunability of magnetic order with carrier density
536 2023-06-15 16:00    [CAPP Seminar] Cryogenic electronics for ion traps file
535 2023-06-14 16:00    [CAPP seminar] EMC at CERN file
534 2016-04-04 09:30    Radio frequency engineering
533 2016-11-1 10:30    Time scale dependent dynamics in InAs/InP quantum dot gain media
532 2018-10-25 16:00    Abelian and non-Abelian dark photons file
531 2024-08-14 11:00    Pair Density Waves and Supercurrent Diode Effect in Altermagnets
530 2017-09-22 16:00    Unexpected Electron-Pairing in Integer Quantum Hall Effect file
529 2017-09-22 14:30    Quantum Electronic Transport in Graphene Hybrid Nanostructures file
528 2024-05-14 16:00    [High Energy Theory Seminar] Minimal Production of Prompt Gravitational Waves during Reheating.
527 2018-12-07 14:30    Spin generation from heat and light in metals file