visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
연사  
장소 KI bldg. 5th fl. Room B501 & Zoom 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 연사 제목
공지 2025-02-24 16:00    2025년 봄학기 콜로키움 안내
공지 2025-02-27 16:00    2025년 봄 물리학과 특별세미나 (광학/응집물리 분야)
575 2015-11-28 10:00    Electron Tunneling Spectroscopy of Single and Bilayer Graphene with Hexagonal Boron Nitride as Tunneling Barrier
574 2015-12-01 16:00    Introducing extra dimensions to spectroscopic studies of advanced quantum materials
573 2015-12-02 16:00    Samarium Hexaboride: Is it a Topological insulator?
572 2015-12-03 16:00    Hybrid solid state spin qubits in wide bandgap semiconductors
571 2015-12-09 11:00    Functional Imaging & Monitoring of Brain & Breast with Diffuse Light
570 2015-12-09 14:00    SWELLABLE COLLOIDAL PARTICLES ARE SWELL
569 2015-12-11 13:30    Quantum spin liquid in the 1/3 depleted triangular lattice Ba3(Ru1-xIrx)Ti2O9
568 2015-12-11 15:45    Dynamical mean field theory studies on heavy fermion system
567 2015-12-17 11:00    Wavefront engineering for in-vivo Deep brain imaging
566 2016-01-11 16:00    Mott Physics in the Strong Spin-Orbit Coupling Regime
565 2016-01-26 14:00    Electrochemistry on Nano- and Atomic Levels: Scanning Probe Microscopy Meets Deep Data
564 2016-03-07 16:00    Physics Colloquium : 2016 Spring file
563 2016-03-11 13:30    Physics Seminar Serises : 2016 Spring file
562 2016-03-11 13:30    Topological phases of matter in nonequilibrium: Topology of the Wannier-Stark ladder
561 2016-03-11 16:00    Jan. Switching handedness of of chiral solitons in Z4 topological insulators
560 2016-04-01 14:30    Interference of single charged particles without a loop and dynamic nonlocality
559 2016-04-01 16:15    Cotunneling drag effect in Coulomb-coupled quantum dots
558 2016-04-04 09:30    Radio frequency engineering
557 2016-04-05 16:00    A new impurity solver for multi-orbital systems: adaptive truncation of the Hilbert space
556 2016-04-06 15:30    Superconducting Quantum Interference Devices for Precision Detection