visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
150 2022-01-11 15:00  E6 #1501  Ultrafast optical studies on CDW collective modes of the Weyl-CDW (TaSe4)2I file
149 2022-01-26 13:00  E6 #1501  An Introduction to Cohomology groups file
148 2022-04-13 10:30  E6 #1323/zoom  Harnessing topology and correlations from singularities in 3d-kagome metals
147 2023-05-17 14:00  E6 #1323  Optical Response in the multilayer thin films
146 2023-04-28 11:00  E6 #1323  Tkachenko wave: From the modern field theory viewpoint
145 2022-10-06 13:00  E6 #1323  Counting States with Global Symmetry
144 2015-07-23 13:30  E4, B401  Enhanced ZnO based UV photonics and related applications file
143 2015-12-17 11:00  E4(KI Building), Matrix Hall (2nd fl.)  Wavefront engineering for in-vivo Deep brain imaging
142 2015-12-09 11:00  E4(KI Building), Connect room (2nd fl.)  Functional Imaging & Monitoring of Brain & Breast with Diffuse Light
141 2015-03-13 14:00  Connect Room, KI Bldg.  The 15th Innovative Workshop on Soft/Bio Materials file
140 2022-09-21 16:00  College of Natural Science E6-2, Rm. 1323  Materials and Device Nanofabrication of Optical Metasurfaces file
139 2023-09-21 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP seminar] Axion Magnetic Resonance file
138 2023-09-14 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP seminar] Dark matter searches in Water Cherenkov Detectors file
137 2023-09-18 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP Seminar] Searching for axions in quantum vacuum birefringence file
136 2023-05-15 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  Role of dark Higgs boson in DM physics and cosmology file
135 2023-06-14 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP seminar] EMC at CERN file
134 2023-06-22 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP Seminar] The muon g-2 puzzle file
133 2023-03-27 15:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  A coherent mechanical oscillator pumped by a suspended quantum dot file
132 2023-07-26 10:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP Seminar] Am Expansive Search for Dark Matter with ADMX and DM Radio
131 2023-06-15 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP Seminar] Cryogenic electronics for ion traps file