visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
246 2023-07-11 11:00  E6-2, #1323  Ordered phases, non-Fermi liquid, and quantum criticality driven by entanglement between multipoles and conduction electrons
245 2023-07-10 16:00  E6, #1323  Electronic structures of magnetic and non-magnetic ordering in d- and f-electrons systems
244 2019-07-10 16:00  Academic Cltural Complex (E9) 5층 스카이라운지  Public Lectures file
243 2016-07-28 16:00  #1323(E6-2. 1st fl.)  Low Dimensional Electrons: On the Road to Hybrid Quantum Systems
242 2022-07-14 15:00  E6 #1501 & Zoom  Pure two-dimensional quantum electron liquid and its phase transition
241 2022-07-14 14:15  E6 #1501 & Zoom  Hund and electronic correlations in ruthenium-based systems
240 2022-07-14 13:30  E6 #1501 & Zoom  Electronic structure and anomalous transport properties of topological materials by first principle calculation
239 2016-07-08 14:00  #1323(E6-2. 1st fl.)  Electronic quasiparticles in the quantum dimer model
238 2016-07-08 11:00  #1323(E6-2. 1st fl.)  Isostatic magnetism
237 2016-07-07 14:00  #1323(E6-2. 1st fl.)  Let there be topological superconductors
236 2019-07-03 15:00  E6-2, 2501  Many-body quantum electrodynamis (QED) with atoms and photons: A new platform for quantum optics" file
235 2023-07-14 11:00  E6-2 #1501  Interfaces engineering of thin film oxides
234 2019-01-23 16:00  Rm. C303, Creation Hall (3F), Munji Campus  Ultrasensitive Microwave Bolometer: Opportunity for Axion Detectors file
233 2020-01-17 16:00  #1323, E6-2  Symmetry Breaking and Topology in Superfluid 3He file
232 2019-01-09 16:00  E6-2. 2nd fl. #2501  Molecular Mott state in the deficient spinel GaV4S8 file
231 2021-01-28 18:00  Online Seminar  Quantum metamaterials: concept, theory, prototypes and possible applications file
230 2021-01-28 15:00  Zoom  Topological Transport of Deconfined Hedgehogs in Magnets file
229 2024-01-16 14:00  E6-2, #1323  Dimer Physics and Superconductivity in La3Ni2O7
228 2019-01-07 15:00  E6-2. 2st fl. #2501  Many-Body Invariants for Multipoles in Higher-Order Topological Insulators file
227 2022-01-26 13:00  E6 #1501  An Introduction to Cohomology groups file