Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
|장소||KI bldg. 5th fl. Room B501 & Zoom|
|일시||Jan. 18(Tue), 2pm-3pm|
|연사||YoungJu Jo (Stanford University)|
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior . Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics .
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
|112||2016/03/11 4 PM||E6-2. 1st fl. #1501||Dr. Tae-Hwan KIM (POSTECH)||Jan. Switching handedness of of chiral solitons in Z4 topological insulators|
|111||Apr. 08 (Fri.), 13:30 PM||E6-2. 1st fl. #1501||Dr. Yunkyu Bang, Chonnam National Univ.||Theoretical Overview of Iron-based superconductors and its future|
|110||2016/03/11 1:30 PM||E6-2. 1st fl. #1501||Dr. Kwon Park||Topological phases of matter in nonequilibrium: Topology of the Wannier-Stark ladder|
|109||2015/10/16, 4PM||E6-2. 2nd fl. #2501||Prof. Yung-Fu Chen(Solid-state Laser Physics Laboratory,National Central University)||Fluctuations of entropy production in partially masked electric circuits|
|108||Jan.9 (Wed.), 04:00 PM||E6-2. 2nd fl. #2501||Dr. Heung-Sik Kim||Molecular Mott state in the deficient spinel GaV4S8|
|107||2015/09/14, 2PM||E6-2. 2nd fl. #2501||Dr. Hae Ja Lee ( Stanford University, SLAC )||Ultrafast X-ray Studies on Dynamics Matter in Extreme Conditions|
|106||Jun. 18 (MON), 10:00 AM||E6-2. 2nd fl. #2502||Dr. Thibault VOGT||Rydberg electromagnetically induced transparency and microwave-to-optical conversion using Rydberg atoms|
|105||NOV. 23 (Fri), 03:00 PM||E6-2. 2st fl. #2501||Prof. Sang-Jin Sin||Entanglement string and Spin Liquid with Holographic duality|
|104||MAR. 26 (TUE), 0300 PM||E6-2. 2st fl. #2501||Prof. Jung Hoon Han||Consideration of thermal Hall effect in frustrated and un-frustrated quantum magnets|
|103||JAN. 7 (Mon), 03:00 PM||E6-2. 2st fl. #2501||Dr. Byoung min Kang||Many-Body Invariants for Multipoles in Higher-Order Topological Insulators|
|102||Sep. 4 (Tue), 02:30 PM||E6-2. 2st fl. #2502||Dr. Changmin Lee, MIT||Ultrafast time- and angle-resolved photoemission spectroscopy (tr-ARPES) with extreme ultraviolet laser pulses|
|101||May. 3 (Fri), 11:00 AM||E6-2. 2st fl. #2502||Prof. Changhee Sohn||Exotic Magnetism|
|100||Apr. 08 (Fri.), 4:00 PM||E6-2. 5st fl. #1501||Dr. Changyoung Kim, SEOUL NATIONAL UNIV.||Spectroscopic studies of iron-based superconductors : what have we learned?|
|99||February 13th (Thur.), 16:30 PM||E6-6, #119||Dr. Seyoon Kim(University of Wisconsin-Madison)||Enhanced Light-Matter Interactions in Graphene with Noble Metal Plasmonic Structures|
|98||2018. 6. 22 10:00am ~ 11:50am||E6-6, Lecture Room 119 (1F)||Prof. Sang Bok Lee, Dept. of Chemistry and Biochemistry, Univ. of Maryland||Success in Research Career|
|97||May 13 (Fri.), 1:30 PM||E6. #1501(1st fl.)||Dr. Young-Woo Son, Dept. of Physics, KIAS||Aperiodic crystals in low dimensions|
|96||May 13 (Fri.) 4 PM||E6. #1501(1st fl.)||Dr. Hosub Jin, Dept. of Physics, UNIST||Graphene analogue in (111)- BaBiO3 bilayer heterostructures for topological electronics|
|95||October 15, 5:00pm||https://bit.ly/3ndIiJn||Dr. Samuli Autti||Time crystals, quasicrystals, and time crystal dynamics in the superfluid universe|
|94||Oct 9 (Fri), 09:00 AM||https://kaist.zoom.us/j/85161896513?pwd=U3pwWFFZaWVRamxDZUR5REhNeVk0UT09||Prof. Tim Hsieh (Perimeter Institute)||Quantum Many-Body Simulation|
|93||Oct. 16 (Fri.), 02:30 PM||https://kaist.zoom.us/j/89198078609||Dr. Chulki Kim||Nanoscale magnetic resonance detection towards nano MRI|