visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
일시 May 22th(Mon), 1:00pm 
장소 E6-6 119 
연사 Dr. John Bosco Balaguru Rayappan (SASTRA Deemed University) 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
 
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)


Abstract:
The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
 
번호 날짜 장소 제목
364 2022-05-27 11:00  Online seminar  Current Status and Future Plans of ADMX file
363 2016-05-24 16:00  E6-2. #1323(1st fl.)  Electronic and magnetic properties of 2D transition-metal thiophosphates and tunability of magnetic order with carrier density
362 2019-05-24 16:00  #1323, E6-2  Infrared spectroscopy study on metal-insulator transitions in layered perovskite iridates file
» 2023-05-22 13:00  E6-6 119  Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers
360 2019-05-21 16:00  #5318, E6-2  Classification of flat bands according to the band-crossing singularity of Bloch wave functions file
359 2019-05-02 16:00  #1323, E6-2  Anomalous optical properties of halide perovskites file
358 2016-05-19 15:00  May 19, 2016 (Thur.) 3PM,  The CERN Resonant WISP Search: Development, Results and Lesson-Learned
357 2016-05-19 16:00  #1323(E6-2, 1st fl.)  Nonlinear/quantum optical effect in silicon nano-photonics
356 2023-05-17 16:30  Zoom  Detecting Hidden Photon Dark Matter via the Excitation of Qubits file
355 2024-05-16 14:30  E6-2 #2502 & Zoom  [Astrophysics Seminar] Observational Cosmology with Superconducting Sensors
354 2016-05-16 16:00  #1323(E6-2, 1st Fl.)  Tuning microwave cavities with biased nonlinear dielectrics for axion searches
353 2024-05-16 16:00  E6-2, #1323  [High Energy Theory Seminar] Conformal Collider Physics
352 2023-05-15 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  Role of dark Higgs boson in DM physics and cosmology file
351 2024-05-14 16:00  E6-2, #2502  [High Energy Theory Seminar] Minimal Production of Prompt Gravitational Waves during Reheating.
350 2016-05-13 13:30  E6. #1501(1st fl.)  Aperiodic crystals in low dimensions
349 2016-05-13 16:00  E6. #1501(1st fl.)  Graphene analogue in (111)- BaBiO3 bilayer heterostructures for topological electronics
348 2016-05-11 16:00  E6-2. #1323(1st fl.)  The quest for novel high-temperature superconductors---Prospects and progress in iridates
347 2019-05-01 16:00  #1323, E6-2  Raman and x-ray scattering study on correlated electron systems: two case examples file
346 2024-05-01 16:00  E6-2 #2502  [High Energy Theory Seminar] Across the Mass Spectrum: Utilizing Small-Scale Structures to Probe Dark Matters
345 2023-05-17 14:00  E6 #1323  Optical Response in the multilayer thin films