visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
장소 KI bldg. 5th fl. Room B501 & Zoom 
일시 Jan. 18(Tue), 2pm-3pm 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 일시 장소 연사 제목
356 3. 21(월),16:00  E6, #1501  이상성교수 (한국천문연구원)  Multi-wavelength Studies on Relativistic Jets from Gamma-ray Bright Active Galactic Nuclei
355 August 1, 2018 at 11:00AM  양분순 빌딩 (E16-1) 207호  이대열 교수, 예일대 석좌교수  Future of AI: Is the brain a computer? file
354 Sep. 11(Fri), 14:00~  zoom  이관형교수/SNU, 이상윤교수/GIST  SRC Seminar file
353 5. 2(월),16:00  E6, #1501  유상운교수 (한밭대)  What can we learn from the history of science and technology?(우리말강의)
352 4pm, 28th April  E6 1323  유경식 (KAIST 전기및전자공학부)  (광학분야 특별세미나)Adiabaticity and symmetry in optical waveguide design
351 2009/02/23-05/04  E6, 1501  안종현교수(성균관대) 외  Physics Colloquium : 2009 Spring file
350 2014/03/10-06/09  E6, 1501  신용일교수(서울대)  Physics Colloquium : 2014 Spring file
349 4pm, 14th April  E6 1323  신승우 (KAIST 물리학과)  (광학분야 특별세미나)Holographic tomography of dielectric tensors at optical frequency
348 3. 7(월),16:00`  E6, #1501  손석우교수 (서울대 지구환경과학부)  Climate Physics and Modelling(우리말강의)
347 2011/05/16, 4PM  E6, 1501  서민교교수(KAIST)  Photonics with surface plasmon polaritons
346 5월 17일(화), 11:00 ~ 12:00  창의학습관(E11), 406호  방준혁 박사(Korea Basic Science Institute, KBSI)  The CERN Resonant WISP Search: Development, Results and Lesson-Learned
345 2013/09/09-12/09  E6, 1501  박혁규교수(부산대) 외  Physics Colloquium : 2013 Fall
344 April 6 (Fri.), 10:00 AM  #2502, E6  박채연 박사  Entanglement and thermalization in many-body systems: recent progress file
343 2015/09/15-12/08  E6, 1501  박제근 교수(서울대 물리학과) 외12명  Physics Colloquium : 2014 Fall file
342 3. 14(월),16:00  E6, #1501  박용근교수 (KAIST 물리학과)  Quantitative phase imaging and artificial intelligence: label-free 3D imaging, classification, and inference
341 5월27일(목) 오후4시  온라인  박소현 박사(CERN) / 이혜성 교수(KAIST)  찾아가는 물리연구 현장(유럽 입자물리학연구소 소개) file
340 2016/03/11-06/09  E6-2, 1501 외  박권(KAIS) 외  Physics Seminar Serises : 2016 Spring file
339 2015/09/07-12/01  E6, 1501  문은국 교수(KAIST) 외  Physics Colloquium : 2015 Fall file
338 4. 11(월),16:00  E6, #1501  노재동교수 (서울시립대 물리학과)  Emergence of Statistical Mechanics in Quantum Systems
337 4. 4(월), 16:00  E6, #1501  김희철교수 (Postech 물리학과)  New paradigms in Quantum Field Theory