visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
연사  
장소 E6-6 119 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
 
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)


Abstract:
The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
 
번호 날짜 연사 제목
공지 2025-02-24 16:00    2025년 봄학기 콜로키움 안내
공지 2025-02-27 16:00    2025년 봄 물리학과 특별세미나 (광학/응집물리 분야)
314 2020-10-16 14:30    Nanoscale magnetic resonance detection towards nano MRI file
313 2020-10-16 16:00    Hidden room-temperature ferroelectricity in CaTiO3 revealed by a metastable octahedral rotation pattern file
312 2020-10-23 14:00    Plasmon spectroscopy of low-dimensional superconductors in fluctuating regime file
311 2020-11-12 16:00    2020 가을학기 광학분야 특별세미나
310 2020-11-17 12:00    Quantum- & Nano-Photonics" 세미나 시리즈 file
309 2020-11-20 14:30    Lumpy Cooper pairs in an iron-based superconductor
308 2020-11-20 16:00    Coherent control of field gradient induced quantum dot spin qubits
307 2020-11-26 16:00    2020 가을학기 광학분야 특별세미나(Light Engineering Beyond the Diffraction Limit)
306 2020-12-02 10:00    Recent progress in Axion Dark Matter eXperiment (ADMX) technology file
305 2020-12-09 10:00    Searching for the QCD axion with the ARIADNE experiment file
304 2020-12-10 13:55    Consistency of Boltzmann equation and light dark matter from inflaton decay
303 2020-12-11 14:30    Antisymmetric interlayer exchange coupling in magnetic multilayers
302 2020-12-11 16:00    Atomic and electronic reconstruction at van der Waals interface in twisted 2D materials
301 2020-12-23 10:00    Online workshop for Quantitative Phase Imaging file
300 2021-01-28 15:00    Topological Transport of Deconfined Hedgehogs in Magnets file
299 2021-01-28 18:00    Quantum metamaterials: concept, theory, prototypes and possible applications file
298 2021-02-02 14:30    Quantum- & Nano-Photonics 세미나(Integrated Nanophotonics with Metamaterials, Microcomb, and Atomic Systems) file
297 2021-02-15 17:00    Magnetic Cluster Octupole Domain evolutation in chiral antiferromagnets file
296 2021-02-17 09:00    석학 대중 강연 및 강의 시리즈 file
295 2021-03-02 16:00    Sensitive terahertz detection with graphene-based transistors file