visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
일시 May 22th(Mon), 1:00pm 
장소 E6-6 119 
연사 Dr. John Bosco Balaguru Rayappan (SASTRA Deemed University) 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
 
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)


Abstract:
The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
 
번호 날짜 장소 제목
166 2022-04-25 16:00  E6, #1501  Ultrafast electron beam, a tool to explore the nanoscopic world of materials(우리말강의)
165 2022-04-28 16:00  E6 1323  (광학분야 특별세미나)Adiabaticity and symmetry in optical waveguide design
164 2022-05-02 16:00  E6, #1501  What can we learn from the history of science and technology?(우리말강의)
163 2022-05-09 16:00  E6, #1501  Searching for new electronic properties in correlated material flatland
162 2022-05-10 16:00  E6 1323  (광학분야 특별세미나)Testing quantum thermodynamics using quantum optics
161 2022-05-11 16:00  E6-2. #1323 & Zoom  Gravity as a phenomenon in quantum dynamics
160 2022-05-12 16:00  E6-2. #1323 & Zoom  New frontiers of electroweak physics at the LHC
159 2022-05-13 14:30  Zoom webinar  Topological Superconducting Spintronics Towards Zero-Power Computing Technologies file
158 2022-05-13 16:00  자연과학동(E6-2) 1st fl. #1323  High-fidelity iToffoli gate for fixed-frequency superconducting qubits file
157 2022-05-16 16:00  E6, #1501  Design synthetic topological matter with atoms and lights
156 2022-05-18 16:00  E6-2. #1323 & Zoom  Geometry, Algebra, and Quantum Field Theory
155 2022-05-19 15:00  online  (광학분야 특별세미나)Development of a multimodal optical system for improved disease diagnosis
154 2022-05-19 15:00  online  (광학분야 특별세미나)Development of a multimodal optical system for improved disease diagnosis
153 2022-05-19 16:00  E6-2. #1323 & Zoom  Chasing Long Standing Neutrino Anomalies with MicroBooNE
152 2022-05-20 11:00  E6-1 #1323  (응집물리 세미나) Exploration of new polymorphs in van der Waals crystals
151 2022-05-23 16:00  E6, #1501  Novel electronic transport in topological van der Waals magnets
150 2022-05-25 14:00  E6 Room(#2501)  Atomic-level insights into ferroelectric switching and preferred orientation of ultrathin hafnia file
149 2022-05-25 16:00  E6-2. 1st fl. #1323 / Zoom  Uncovering New Lampposts for Dark Matter: Continuum or Conformal
148 2022-05-26 16:00  E6 1323  (광학분야 특별세미나)Topological photonic devices
147 2022-05-27 11:00  Online seminar  Current Status and Future Plans of ADMX file