visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
479 2019-06-04 17:00  #1323, E6-2  Stochastic nature of bacterial eradication using antibiotics file
478 2019-05-31 11:00  #1323, E6-2  Cavity QED with Spin Qubits file
477 2019-05-24 16:00  #1323, E6-2  Infrared spectroscopy study on metal-insulator transitions in layered perovskite iridates file
476 2019-05-30 16:00  #1323, E6-2  Tuning the excitonic properties of semiconductors with light-matter interactions file
475 2019-11-14 16:00  #1323, E6-2  Semi-classical model of polariton propagation file
474 2019-11-28 16:00  #1323, E6-2  Generation of coherent EUV emissions using ultrashort laser pulses file
473 2019-12-03 16:00  #1323, E6-2  Toward Quantum Materials with Correlated Oxides file
472 2019-12-05 16:00  #1323, E6-2  Subwavelenth Photonic Devices: From Single Photon Sources to Solar Cell file
471 2019-12-13 13:30  #1323, E6-2  Biophysics Mini-symposium at KAIST file
470 2019-12-18 16:00  #1323, E6-2  Road to Higher Tc Superconductivity file
469 2019-06-17 10:30  #1323, E6-2  Chiral Spintronics file
468 2019-06-28 13:30  #1323, E6-2  Magnetic domains and domain wall conduction in pyrochlore iridate thin films and heterostructures file
467 2019-07-30 16:00  #1323, E6-2  Dirac fermions and flat bands in correlated kagome metals file
466 2019-08-22 16:00  #1323, E6-2  Physics and Applications in Nanoelectronics and Nonomechanics file
465 2019-09-18 16:00  #1323, E6-2  Exploring Synthetic Quantum Matter in Superconducting Circuits file
464 2019-09-26 16:00  #1323, E6-2  Entanglement Swapping with Autonomous Polarization-Entangled Photon-Pairs from Warm Atomic Ensemble file
463 2019-10-15 16:00  #1323, E6-2  Moiré superlattices and graphene quasicrystal file
462 2019-10-17 16:00  #1323, E6-2  Top down manipulation of Waves : From Metamaterials, Correlated Disorder, Quantum Analogy, to Digital Processing file
461 2019-10-25 15:00  #1323, E6-2  Physics Seminar file
460 2019-10-29 14:30  #1323, E6-2  Quantum sensing file