Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
|장소||KI bldg. 5th fl. Room B501 & Zoom|
|일시||Jan. 18(Tue), 2pm-3pm|
|연사||YoungJu Jo (Stanford University)|
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior . Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics .
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
|공지||Sep.22 2022||E6-1 #1323||2022 가을학기 응집물리 및 광학 세미나 전체 일정|
|242||2010/02/14-05/09||E6, 1501||황철주(주성엔지니어링 사장) 외||Physics Colloquium - 2011 Spring|
|241||2010/09/06-12/06||E6, 1501||조호진기자(조선일보) 외||Physics Colloquium : 2010 Fall|
|240||2010/02/08-05/03||E6, 1501||최인수교수(서울대) 외||Physics Ciolloquium : 2010 Spring|
|239||2009/10/21, 4PM||E6, 1501||최석봉교수(서울대)||Interdimensional Universality of Dynamic Interfaces|
|238||2009/09/07-11/30||E6, 1501||이주영박사(KIAS) 외||Physics Colloquium : 2009 Fall|
|237||2009/02/23-05/04||E6, 1501||안종현교수(성균관대) 외||Physics Colloquium : 2009 Spring|
|236||2014/12/22, 2PM||E6, Rm1319||Prof. Changbong Hyeon (KIAS)||Dynamics of molecular motors: Power stroke vs Brownian ratchet|
|235||Aug.12(Fri.) 10:00AM, 2022||E6-1 #1323||Dr. Moon Jip Park (Center for Theoretical Physics of Complex Systems, IBS)||Twisted Bilayer Magnets|
|234||April 08(Fri.) 11:00||E6-1 #1323||Prof. Se-Young Jeong (Optics and Mechatronics Engineering , Pusan National University)||(응집물리 세미나) Flat-surface-assisted physical phenomena occurring in single crystal metal thin film|
|233||Mar. 25(Fri.) 11:00||E6-1 #1323||Prof. Ara Go (Department of Physics, Chonnam National University)||(응집물리 세미나) Hund's metallicity in ruthenate systems|
|232||May 20(Fri.) 11:00||E6-1 #1323||Prof. Kwanpyo Kim (Department of Physics, Yonsei University)||(응집물리 세미나) Exploration of new polymorphs in van der Waals crystals|
|231||Aug.18 (Thr), 10:00 AM||E6-1 #1323||Dr. Kyoung-Min Kim (Center for Theoretical Physics of Complex Systems, IBS)||Disorder-driven phase transition in the second-order non-Hermitian skin effect|
|230||Sep. 21(Wed.) 10:30~12:00||E6-1 #1501||Pablo Jarillo-Herrero(Department of Physics, MIT)||Distinguished Lecture 'The Magic of Moiré Quantum Matter'|
|229||October 24 (Wed.), 10:30 AM||E6-1, Lecture Room 1501(1F)||Prof. Kerry J. Vahala||Photonic integration of next-generation clocks and Hertz-absolute-accuarcy optical frequenncy synthesizers|
|228||DEC. 26 (Wed), 04:00 PM||E6-1. 3rd fl. #3434||Y. Kim, A. Go, K. Hwang and E.-G. Moon||Informal Workshop on Topology and Correlation|
|227||Nov. 11 (Fri), 11:00AM||E6-2 #1323||손창희(UNIST 물리학과 교수)||(응집물리 세미나) Honeycomb oxide heterostructures for quantum spin liquid|
|226||Sep. 29 (Thu), 4:00PM||E6-2 #1323||강봉주(한국화학연구원 박사)||(광학분야 세미나) Ultrafast THz Field-Induced Nonlinear Optics|
|225||Oct. 28 (Fri), 11:00AM||E6-2 #1323||김수란(경북대 물리교육과 교수)||(응집물리 세미나) Machine-Learning-Guided Prediction models and Materials discovery for high Tc cuprates|
|224||Oct. 13 (Thu), 4:00PM||E6-2 #1323||김영진(KAIST 기계공학과 교수)||(광학분야 세미나) Ultrafast Optics for Ultra-Precision Metrology and Realization of Flexible/Stretchable Laser-Induced-Graphene Electronics|