visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2024-01-24 15:00 
일시 Jan 24th(Wed), 15:00 
장소 E6-2 #1323 
연사 Myung Hyun Jo (Boston Children's Hospital, Harvard Medical School) 
물리학과 구성원분들께,
 
아래와 같이 세미나를 개최하오니, 관심있는 분들의 많은 참석 부탁드립니다.
 
* Title: Determination of single molecule loading rate during mechanotransduction
 
* Speaker: Myung Hyun Jo  (Boston Children's Hospital, Harvard Medical School)  조명현 박사
 
* Date: 3pm, 24th January 2024 (Wednesday)
 
* Place: E6 1323 (no zoom broadcasting)
 
Abstract:
Cells connect with their environment via surface receptors and utilize physical tension in receptor-ligand bonds for various cellular processes. Single-molecule techniques have revealed bond strength by measuring 'rupture force' but it has been long recognized that rupture force is dependent on the loading rate – how quickly force is ramped up. Therefore, the physiological loading rate must be determined to reveal the mechanical strength of individual bonds in their functional context. Here, we developed an overstretching tension sensor (OTS) allowing for more accurate force measurement in physiological conditions with single-molecular detection sensitivity even in mechanically dense and dynamic focal adhesions. Serially connected OTSs show that the physiological loading rate ranges from 0.5–4 pN/s and is about three times higher in leukocytes than in epithelial cells. 
 
Contact: Yongsoo Yang (yongsoo.yang@kaist.ac.kr)
번호 날짜 장소 제목
542 2009-02-23 16:00  E6, 1501  Physics Colloquium : 2009 Spring file
541 2009-09-07 16:00  E6, 1501  Physics Colloquium : 2009 Fall file
540 2009-10-21 16:00  E6, 1501  Interdimensional Universality of Dynamic Interfaces
539 2010-02-08 16:00  E6, 1501  Physics Ciolloquium : 2010 Spring file
538 2010-02-14 16:00  E6, 1501  Physics Colloquium - 2011 Spring file
537 2010-09-06 16:00  E6, 1501  Physics Colloquium : 2010 Fall file
536 2011-05-16 16:00  E6, 1501  Photonics with surface plasmon polaritons
535 2011-09-03 16:00  E6, 1501  Physics Colloquium : 2011 Fall file
534 2012-02-13 16:00  E6, 1501  Physics Colloquium : 2012 Spring
533 2012-04-02 16:00  E6, 1501  A new route to ferroelectricity in magnetic spinels: a case of Co2MnO4
532 2013-03-11 16:00  E6, 1501  Physics Colloquium : 2013 Spring
531 2013-09-09 16:00  E6, 1501  Physics Colloquium : 2013 Fall
530 2014-03-10 16:00  E6, 1501  Physics Colloquium : 2014 Spring file
529 2014-05-28 17:00  KI Building, Matrix Hall  부품소재산업이 미래다
528 2014-12-22 14:00  E6, Rm1319  Dynamics of molecular motors: Power stroke vs Brownian ratchet file
527 2015-03-04 12:00  1323호, E6-2  Bioimaging and Biosensing Using Near-Infrared Fluorescence file
526 2015-03-09 16:00  E6, 1501  Physics Colloquium : 2015 Spring file
525 2015-03-13 14:00  Connect Room, KI Bldg.  The 15th Innovative Workshop on Soft/Bio Materials file
524 2015-06-03 12:00  Room 101, E11  The First Wednesday Multidisciplinary Forum file
523 2015-07-15 14:00  E6-2,1323  Electronic and optical properties of titanate-based oxide superlattices