visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
일시 May 22th(Mon), 1:00pm 
장소 E6-6 119 
연사 Dr. John Bosco Balaguru Rayappan (SASTRA Deemed University) 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
 
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)


Abstract:
The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
 
번호 날짜 장소 제목
422 2016-04-12 16:00  E6-2. 1st fl. #1323  Confinement of Superconducting Vortices in Magnetic Force Microscopy
421 2017-04-28 14:30  E6-2. 1st fl. #1323  Hot electron generation at surfaces and its impact to catalysis and renewable energy conversion
420 2015-12-11 15:45  E6-2, #1323  Dynamical mean field theory studies on heavy fermion system
419 2023-10-19 11:00  E6-2 #1322  Emergent functionalities of iridium oxide films with different growth orientation file
418 2023-06-26 11:00  E6, Rm#1323  Quantum computing on magnetic racetracks with flying domain wall qubits
417 2019-04-19 11:00  #1323, E6-2  First-principles studies of semiconductors for solar cell applications file
416 2021-06-11 14:30  Online seminar  Engineering sound waves and vibrations in multi-mode nanomechanical systems file
415 2019-09-27 16:00  E6-2. 1st fl. #1323  0D/1D/2D/3D III-V materials grown by MBE for Optelectronics file
414 2018-03-16 14:30  E6-2. 1st fl. #1323  산화물 다층박막에서의 다양한 물리현상 file
413 2018-03-16 14:30  E6-2. 1st fl. #1323  산화물 다층박막에서의 다양한 물리현상 file
412 2016-12-8 16:00  #1323(E6-2. 1st fl.)  Dynamical Resonance between Two Optical Cavities via Optomechanical Oscillator
» 2023-05-22 13:00  E6-6 119  Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers
410 2017-03-02 16:00  #1323(E6-2. 1st fl.)  “Progress in the comparison of ARPES to DMFT for d and f strongly correlated electron systems”
409 2019-12-03 16:00  #1323, E6-2  Toward Quantum Materials with Correlated Oxides file
408 2016-04-01 16:15  E6-2. 1st fl. #1501  Cotunneling drag effect in Coulomb-coupled quantum dots
407 2015-08-03 10:30  E6-2, #1323 (Seminar Room)  Axion Search
406 2016-11-04 13:30  E6-2. #1323(1st fl.)  Exotic phenomena at oxide LaAlO3/SrTiO3 hetero-interface and their applications
405 2018-10-19 10:00  #1323, E6-2  Energy conversion processes during magnetic reconnection in a laboratory plasma file
404 2018-12-07 16:00  E6-2. 1st fl. #1323  Novel probes of interacting electrons in 2D systems file
403 2019-09-27 14:30  E6-2. 1st fl. #1323  Spin-charge conversion in topological insulators for spintronic applications file