visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
219 2022-08-12 10:00  E6-1 #1323  Twisted Bilayer Magnets file
218 2022-08-12 10:00  E6-1 #1323  Twisted Bilayer Magnets file
217 2022-08-18 10:00  E6-1 #1323  Disorder-driven phase transition in the second-order non-Hermitian skin effect
216 2014-12-22 14:00  E6, Rm1319  Dynamics of molecular motors: Power stroke vs Brownian ratchet file
215 2023-09-27 16:00  E6, Rm#2501  Chiral Magnets: Domain-Wall Skyrmions and String Theory Realization
214 2023-06-26 11:00  E6, Rm#1323  Quantum computing on magnetic racetracks with flying domain wall qubits
213 2023-08-24 11:00  E6, Rm#1323  Advancing magnonic metamaterials: spin waves in nanomagnetic arrays
212 2009-02-23 16:00  E6, 1501  Physics Colloquium : 2009 Spring file
211 2009-09-07 16:00  E6, 1501  Physics Colloquium : 2009 Fall file
210 2009-10-21 16:00  E6, 1501  Interdimensional Universality of Dynamic Interfaces
209 2010-02-08 16:00  E6, 1501  Physics Ciolloquium : 2010 Spring file
208 2010-09-06 16:00  E6, 1501  Physics Colloquium : 2010 Fall file
207 2010-02-14 16:00  E6, 1501  Physics Colloquium - 2011 Spring file
206 2011-05-16 16:00  E6, 1501  Photonics with surface plasmon polaritons
205 2011-09-03 16:00  E6, 1501  Physics Colloquium : 2011 Fall file
204 2012-02-13 16:00  E6, 1501  Physics Colloquium : 2012 Spring
203 2012-04-02 16:00  E6, 1501  A new route to ferroelectricity in magnetic spinels: a case of Co2MnO4
202 2013-03-11 16:00  E6, 1501  Physics Colloquium : 2013 Spring
201 2013-09-09 16:00  E6, 1501  Physics Colloquium : 2013 Fall
200 2014-03-10 16:00  E6, 1501  Physics Colloquium : 2014 Spring file