visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
공지 2022-11-25 11:00  E6-2 #1323  [Update 세미나영상](응집물리 세미나) DMFT+ NRG: From models to real materials, from local to nonlocal correlations
108 2019-12-13 13:00  #2501, E6-2  Computational Material Designs: Current Status and Future Directions file
107 2016-04-28 15:00  #2501(E6-2. 2nd fl.)  Lattice/Spin/Charge Coupling in 5d Pyrochlore Cd2Os2O7
106 2019-09-02 16:00  Seminar Room 1501  Fall 2019: Physics Colloquium file
105 2016-10-17 11:00  #1323,(E6-2, 1st fl.)  IMS and examples of the studies on optoelectronic materials
104 2020-02-20 16:00  #1323, E6-2  Unconventional superconductivity in the locally non-centrosymmetric heavy-fermion CeRh2As2 file
103 2020-01-17 16:00  #1323, E6-2  Symmetry Breaking and Topology in Superfluid 3He file
102 2019-12-18 16:00  #1323, E6-2  Road to Higher Tc Superconductivity file
101 2019-12-13 13:30  #1323, E6-2  Biophysics Mini-symposium at KAIST file
100 2019-12-05 16:00  #1323, E6-2  Subwavelenth Photonic Devices: From Single Photon Sources to Solar Cell file
99 2019-12-03 16:00  #1323, E6-2  Toward Quantum Materials with Correlated Oxides file
98 2019-11-28 16:00  #1323, E6-2  Generation of coherent EUV emissions using ultrashort laser pulses file
97 2019-11-14 16:00  #1323, E6-2  Semi-classical model of polariton propagation file
96 2019-11-07 16:00  #1323, E6-2  Integrated quantum photonics with solid-state quantum emitters file
95 2019-11-05 16:00  #1323, E6-2  Study on nanomaterials by the development of ultrahigh resolution laser-photoelectron microscopy (PEEM) file
94 2019-10-29 14:30  #1323, E6-2  Quantum sensing file
93 2019-10-25 15:00  #1323, E6-2  Physics Seminar file
92 2019-10-17 16:00  #1323, E6-2  Top down manipulation of Waves : From Metamaterials, Correlated Disorder, Quantum Analogy, to Digital Processing file
91 2019-10-15 16:00  #1323, E6-2  Moiré superlattices and graphene quasicrystal file
90 2019-09-26 16:00  #1323, E6-2  Entanglement Swapping with Autonomous Polarization-Entangled Photon-Pairs from Warm Atomic Ensemble file
89 2019-09-18 16:00  #1323, E6-2  Exploring Synthetic Quantum Matter in Superconducting Circuits file