visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
227 2023-12-14 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  Superconducting qubits for large-scale quantum computers file
226 2023-04-13 11:00  Zoom  [High Energy Theory Seminar]Noninvertible Gauss Law and Axions
225 2015-12-01 16:00  E6-2, #1323  Introducing extra dimensions to spectroscopic studies of advanced quantum materials
224 2015-11-10 16:00  E6-2, #1323  Rapid heating of matter using high power lasers
223 2022-11-10 16:00  E6-2. 1st fl. #1323  Probing the Origin of Cosmic Infrared Background and Future Prospects with SPHEREx
222 2023-02-28 11:00  E6 Room(#1322)  Topotactic redox engineering toward novel material file
221 2018-10-16 10:00  #1323, E6-2  Capturing protein cluster dynamics and gene expression output in live cells file
220 2018-06-18 10:00  E6-2. 2nd fl. #2502  Rydberg electromagnetically induced transparency and microwave-to-optical conversion using Rydberg atoms file
219 2019-03-29 16:00  E6-2. 1st fl. #1323  Coherent Quantum Control and Magnetism on atoms – Trapped ion and ESR STM file
218 2023-09-26 16:00  E6-2, #2502  [High Energy Theory Seminar]A new step in interacting dark sector cosmologies
217 2016-03-11 16:00  E6-2. 1st fl. #1501  Jan. Switching handedness of of chiral solitons in Z4 topological insulators
216 2021-04-02 14:30  Online(Zoom)  Quantum computing and entanglement generation using trapped ions and photons
215 2021-05-14 14:30  Online seminar  Electrically tunable spin valve effect in vertical van-der-Waals magnetic tunnel junctions file
214 2015-11-28 10:00  E6-2, #1323  Electron Tunneling Spectroscopy of Single and Bilayer Graphene with Hexagonal Boron Nitride as Tunneling Barrier
213 2022-05-11 16:00  E6-2. #1323 & Zoom  Gravity as a phenomenon in quantum dynamics
212 2022-05-25 16:00  E6-2. 1st fl. #1323 / Zoom  Uncovering New Lampposts for Dark Matter: Continuum or Conformal
211 2019-05-01 16:00  #1323, E6-2  Raman and x-ray scattering study on correlated electron systems: two case examples file
210 2018-04-13 10:00  #1323 (E6-2, 1st fl.)  Quantum meets Mechanics: from Quantum Information to Fundamental Research file
209 2022-09-30 14:30  E6-2. 1st fl. #1323 & Zoom  Putting a spin on the Josephson effect file
208 2022-07-14 15:00  E6 #1501 & Zoom  Pure two-dimensional quantum electron liquid and its phase transition