visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2023-05-22 13:00 
일시 May 22th(Mon), 1:00pm 
장소 E6-6 119 
연사 Dr. John Bosco Balaguru Rayappan (SASTRA Deemed University) 
물리학과 이원희 교수 연구실에서 SASTRA Deemed University의 Professor. Rayappan을 초청하여 세미나를 개최합니다.
구성원 여러분들의 많은 관심과 참여 부탁 드립니다.
 
* Title: Design & Development of Electrochemical Biosensors for the Detection of T2DM Biomarkers 

* Speaker: Dr. John Bosco Balaguru Rayappan

* Date: 1:00 pm, 22th may 2023 (Monday)

* Place: E6-6 119 (no zoom broadcasting)


Abstract:
The screening of diabetes complications may greatly benefit from the adoption of point-of-care devices for detecting diabetes biomarkers in human blood plasma and urine samples. Preeminent Methylglyoxal (MG) and Carboxymethyl-lysine (CML) levels lead to various diseases and diabetes complications. Therefore, MG and CML are considered to be the potential biomarkers of diabetes mellitus, which are produced in the Maillard reaction and involved in the formation of advanced glycation end-products. In this background, we have developed electrochemical biosensors for the detection of MG and CML in human blood plasma and urine samples. An enzyme-based electrochemical MG biosensor was developed with a linear range of 1.0 - 7.5 μM concentration, sensitivity of 1.02 mA μM-1, limit of detection of 0.21 μM, limit of quantification of 0.70 μM and response time less than 10 s. The developed sensor was validated with 350 clinical samples and it exhibited a 90% of correlation with ELISA data. In addition, an enzyme-free antibody-based electrochemical sensor for the detection of CML was developed and it exhibited a linear range of 10 ng mL-1 – 500 μg mL-1. To obtain more accuracy in detecting the complications of diabetes, one can adopt a simultaneous detection of both MG and CML analytes with the multi-probe channel system.
 
번호 날짜 장소 제목
531 2024-03-28 11:00  E6, #2501  Geometric characterization of thermoelectric performance of two-dimensional quadratic band-crossing semimetals
530 2024-03-27 16:00  E6-2, #2502  [High Energy Theory Seminar] The Callan Rubakov Effect
529 2024-03-20 16:00  E6-2 #2502  [High-Energy Theory Seminar] Black hole states at finite N
528 2024-03-13 16:00  E6-2 #2502  [High-Energy Theory Seminar] The Schwarzschild Black Hole from Perturbation Theory to all Orders
527 2024-03-08 11:00  E6-2 #1323  2024 봄학기 광학분야 및 응집물리 특별세미나 전체 일정 file
526 2024-03-07 16:00  Zoom  [CAPP seminars] Development of Superconducting Transition Edge Sensors at SRON file
525 2024-02-26 16:00  E6-1 #1501  2024 봄학기 콜로키움 전체 일정 file
524 2024-02-16 10:00  E6, #1323  Optical conductivity of superconducting states driven by Van Hove singularities
523 2024-01-26 15:00  E6-2 #1323  In-situ 4D-STEM studies on surface reconstruction and polarization switching of perovskite oxides
522 2024-01-25 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  [CAPP seminars] Detecting Gravitational Waves by Elecromagnetic Cavity
521 2024-01-24 15:00  E6-2 #1323  Determination of single molecule loading rate during mechanotransduction file
520 2024-01-16 16:00  E6-2, #2502  [High Energy Theory Seminar] Towards quantum black hole microstates
519 2024-01-16 14:00  E6-2, #1323  Dimer Physics and Superconductivity in La3Ni2O7
518 2024-01-03 11:00  E6-2, #1323  Interplay of Strong Correlations, Topology, and Disorder in 2D Quantum Matters
517 2023-12-19 16:00  E6-2, #1323  [High Energy Theory Seminar] Non-invertible symmetries, leptons, quarks, and why multiple generations
516 2023-12-14 16:00  CAPP Seminar Room C303, Creation Hall, KAIST Munji Campus  Superconducting qubits for large-scale quantum computers file
515 2023-12-08 10:30  E6-2, Rm#2502  Novel transport phenomena in insulators
514 2023-11-30 10:30  E6-2, #1322  [High-Energy Theory Seminar] 3d-3d correspondence and 2d N = (0,2) boundary conditions
513 2023-11-29 10:00  Zoom  [High Energy Theory Seminar] Averaged null energy and the renormalization group
512 2023-11-23 16:00  E6-2(Natural Science B/D). 1st fl. #1323  Deciphering the Enigma of Quantum Materials by X-ray Scattering and Spectroscopy