Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo
|장소||KI bldg. 5th fl. Room B501 & Zoom|
|일시||Jan. 18(Tue), 2pm-3pm|
|연사||YoungJu Jo (Stanford University)|
18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501
회의 ID: 895 860 324 30
Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo
PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University
Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior . Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics .
1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.
2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.
3. Jo et al. in preparation.
4. Sylwestrak*, Vesuna*, Jo* et al. in revision.
문의: 박용근 교수 (내선:2514)
|360||Jul. 28 (Thu.) 4PM||#1323(E6-2. 1st fl.)||Prof. Johannes Pollanen, Jerry Cowen Chair of Experimental Physics at Michigan State University||Low Dimensional Electrons: On the Road to Hybrid Quantum Systems|
|359||Jul. 08 (Fri.) 2PM||#1323(E6-2. 1st fl.)||Dr. Junhyun Lee, Harvard University||Electronic quasiparticles in the quantum dimer model|
|358||Jul. 07 (Thu.) 2PM||#1323(E6-2. 1st fl.)||Dr. Eun Ah Kim, CORNELL UNIV.||Let there be topological superconductors|
|357||Jul. 08 (Fri.) 11:00 AM||#1323(E6-2. 1st fl.)||Dr. Michael Lawler(Binghampton Univ. / Cornell Univ.)||Isostatic magnetism|
|356||Apr. 19(Tue.), 2PM||#1323(E6-2. 1st fl.)||Prof. Mark Koepke, Department of Physics and Astronomy, West Virginia University, USA||Nonlocal collisional electron transport in partially ionized plasma generation, structure, and stability|
|355||2019/09/18 - 12/5||Seminar Room #1323||Prof. David Schuster and etc.||Fall 2019: Physics Seminar Serises|
|354||February 20 (Thu), 4:00 PM||#1323, E6-2||Seunghyun Khim||Unconventional superconductivity in the locally non-centrosymmetric heavy-fermion CeRh2As2|
|353||January 17 (Fri), 4:00 PM||#1323, E6-2||Hiroki Ikegami||Symmetry Breaking and Topology in Superfluid 3He|
|352||December 18 (Tue.), 4:00 PM||#1323, E6-2||Prof. Shin-ichi Uchida||Road to Higher Tc Superconductivity|
|351||December 13 (Fri.), 1:30-4:30 PM||#1323, E6-2||Biophysics Mini-symposium at KAIST|
|350||December 5 (Thu.), 16:00 PM||#1323, E6-2||Prof. Soon-Hong Kwon||Subwavelenth Photonic Devices: From Single Photon Sources to Solar Cell|
|349||December 3 (Tue.), 4:00 PM||#1323, E6-2||Dr. Jong Mok Ok||Toward Quantum Materials with Correlated Oxides|
|348||November 28 (Thu.), 16:00 PM||#1323, E6-2||Prof. Kyung Taec Kim||Generation of coherent EUV emissions using ultrashort laser pulses|
|347||November 14 (Thu.), 16:00 PM||#1323, E6-2||Prof. Ji-Hun Kang||Semi-classical model of polariton propagation|
|346||June 22 (Fri.), 04:00 PM||#1323, E6-2||Dr. Daniel Sando||Tuning functional properties of BiFeO3 films using strain and growth chemistry|
|345||June 22 (Fri.), 04:00 PM||#1323, E6-2||Dr. Daniel Sando||Tuning functional properties of BiFeO3 films using strain and growth chemistry|
|344||November 7 (Thu.), 16:00 PM||#1323, E6-2||Prof. Je-Hyung Kim||Integrated quantum photonics with solid-state quantum emitters|
|343||November 5 (Tue.), 4:00 PM||#1323, E6-2||Dr. Shik Shin||Study on nanomaterials by the development of ultrahigh resolution laser-photoelectron microscopy (PEEM)|
|342||October 29 (Tue.), 14:30 PM||#1323, E6-2||Prof. Jörg Wrachtrup||Quantum sensing|
|341||Oct. 25 (Fri), 15:00 ~||#1323, E6-2||Daesu Lee,Junwoo Son,MyungJoon Han ,Siheon Ryee,Eun-Gook Moon||Physics Seminar|