visual
visual

세미나

  • HOME
  • >
  • 소식
  • >
  • 세미나
날짜 2022-01-18 14:00 
일시 Jan. 18(Tue), 2pm-3pm 
장소 KI bldg. 5th fl. Room B501 & Zoom 
연사 YoungJu Jo (Stanford University) 

[Seminar]

18 Jan 2022, Tue, 2pm-3pm, KI bldg. 5th fl. Room B501

Zoom: https://kaist.zoom.us/j/89586032430

회의 ID: 895 860 324 30

 

Data-driven interrogation of biological dynamics:
from subcellular interactions to neuronal networks in vivo

 

 

YoungJu Jo

PhD Candidate in Applied Physics, Deisseroth Laboratory, Stanford University

 

 

Biological systems are nonlinear dynamical systems consisting of heterogeneous entities. Understanding the logic of the complex spatiotemporal dynamics in such systems, robustly implementing specific biological functions, may require new approaches beyond the traditional hypothesis-driven experimental designs. Here we present a data-driven approach, enabled by high-throughput experimental and computational technologies, across multiple scales. We first discuss a computational imaging technique for simultaneously visualizing multiple aspects of subcellular dynamics [1, 2], its potential combination with molecular optogenetics to study the cell signaling networks, and the remaining challenges in these systems. Then we turn to neuronal networks in behaving animals where high-dimensional neural population activity could be reliably measured and perturbed over extended time. Synergizing with recent technical advances, we propose and experimentally demonstrate a unified deep learning framework to identify the underlying neural dynamical systems, reverse-engineer the neural computation implemented by the dynamics, and design spatiotemporally patterned optogenetic stimulation for naturalistic manipulation of animal behavior [3]. Application of this framework to the mouse habenular circuitry reveals cell-type-specific reward history coding implemented by line attractor dynamics [4].

 

References:

1. Jo*, Park* et al. Science Advances 3(8), e1700606, 2017.

2. Jo*, Cho*, Park* et al. Nature Cell Biology 23, 1329–1337, 2021.

3. Jo et al. in preparation.

4. Sylwestrak*, Vesuna*, Jo* et al. in revision.

 

문의: 박용근 교수 (내선:2514)

 

 

번호 날짜 장소 제목
» 2022-01-18 14:00  KI bldg. 5th fl. Room B501 & Zoom  Data-driven interrogation of biological dynamics: from subcellular interactions to neuronal networks in vivo file
190 2022-01-25 15:00  E6 #1501/online  Emulating twisted double bilayer graphene with a multiorbital optical lattice file
189 2022-01-26 13:00  E6 #1501  An Introduction to Cohomology groups file
188 2022-02-28 16:00  E6, #1501  Spin-based training of optical microscopes
187 2022-03-07 16:00  E6, #1501  Climate Physics and Modelling(우리말강의)
186 2022-03-14 16:00  E6, #1501  Quantitative phase imaging and artificial intelligence: label-free 3D imaging, classification, and inference
185 2022-03-18 11:00  Online seminar  (응집물리 세미나) Illuminating exotic states of matter: Raman spectroscopy as an experimental tool to characterize quantum spin liquids file
184 2022-03-21 16:00  E6, #1501  Multi-wavelength Studies on Relativistic Jets from Gamma-ray Bright Active Galactic Nuclei
183 2022-03-25 11:00  E6-1 #1323  (응집물리 세미나) Hund's metallicity in ruthenate systems file
182 2022-03-28 16:00  E6, #1501  Ultimate-density atomic semiconductor via flat bands
181 2022-03-29 10:00  E6 #1501/zoom, E6 #2502/zoom  Non-reciprocal phase transitions file
180 2022-03-31 10:00  E6 #1501/zoom  Weiss fields for Quantum Spin Dynamics file
179 2022-03-31 16:00  online  (광학분야 특별세미나)Ultrafast time-resolved spectroscopy in topological materials
178 2022-04-01 16:00  Zoom webinar  High-field Electron Transport and Interaction Induced Phenomena in 2D Materials file
177 2022-04-04- 16:00  E6, #1501  New paradigms in Quantum Field Theory
176 2022-04-08 11:00  E6-1 #1323  (응집물리 세미나) Flat-surface-assisted physical phenomena occurring in single crystal metal thin film file
175 2022-04-11 16:00  E6, #1501  Emergence of Statistical Mechanics in Quantum Systems
174 2022-04-13 10:30  E6 #1323/zoom  Harnessing topology and correlations from singularities in 3d-kagome metals
173 2022-04-14 16:00  E6 1323  (광학분야 특별세미나)Holographic tomography of dielectric tensors at optical frequency
172 2022-04-15 11:00  Online seminar  (응집물리 세미나) First-principles studies of polar oxides and their applications file